Chloroquine resistant malaria prophylaxis

Discussion in 'Aralen' started by avernik, 11-Mar-2020.

  1. sn2006 User

    Chloroquine resistant malaria prophylaxis


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Pregnancy. There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant women; usage during pregnancy should be avoided except in prophylaxis or treatment of malaria when benefit outweighs potential risk to fetus. Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Chloroquine is related in structure to quinine but more potent against Plasmodium falciparum, ovale, malariae and vivax, and better tolerated than quinine. Chloroquine remains the first choice of antimalarial prophylaxis as well as treatment. Chloroquine is available in tablets of 250 and 500 mg in generic forms and under the brand name Aralen.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine resistant malaria prophylaxis

    CDC - Malaria - Travelers - Choosing a Drug to Prevent Malaria, Chloroquine Oral Uses, Side Effects, Interactions, Pictures.

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  7. Chloroquine or hydroxychloroquine. No harmful effects on the fetus have been observed when chloroquine or hydroxychloroquine are used in the recommended doses for malaria prophylaxis. 2 Observational data 5, 6 amounting to more than 1000 exposures and 1 double-blind randomized-controlled trial 7 N = 951 have evaluated the use of chloroquine at various stages of pregnancy for the prevention.

    • Prophylactic use of antimalarials during pregnancy.
    • Chloroquine - LiverTox - NCBI Bookshelf.
    • Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health..

    Chloroquine is used for the prophylaxis of malaria in areas of the world where the risk of chloroquine-resistant falciparum malaria is still low. It is also used with proguanil when chloroquine-resistant falciparum malaria is present. However, this combination may not be ideal. Chloroquine should not be taken for prophylaxis by patients with a history of epilepsy. Precautions If the condition of the patient deteriorates after administration of chloroquine, resistance must be suspected and quinine must be administered intravenously as an emergency measure. Chloroquine is the drug of choice for people who travel to these areas; however, resistance to chloroquine is now widespread in all areas of the world where malaria is endemic, but it is still an effective choice for prophylaxis in travelers to Mexico, the Caribbean, Central America, Argentina.

     
  8. vikpis XenForo Moderator

    Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. What Are Malaria Pills? Do They Prevent and Treat Malaria? Do you need a prescription to buy chloroquine in Australia. Anti-Malaria Tablets Without A Prescription LloydsPharmacy
     
  9. Turmalina Guest

    Chloroquine phosphate C18H32ClN3O8P2 - PubChem Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase.

    Aquarium Fish Chloroquine A "New" Drug for Treating Fish.
     
  10. rypy XenForo Moderator

    Drug Name Brand Name Manufacturer Program Contact. Hydroxychloroquine Plaquenil® Sanofi‐Synthelabo Inc. Sanofi Patient Assistance Program 1‐800‐992‐9022 Infliximab Remicade® Centocor, US Remicade Patient Assistance Program 1‐866‐489‐5957 Leflunomide Arava® Sanofi Aventis Sanofi Aventis Pharmaceuticals Patient Assistance Program

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