Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Rheumatoid arthritis chloroquine Hydroxychloroquine patient Retinal imaging takes a digital picture of the back of your eye. It shows the retina where light and images hit, the optic disk a spot on the retina that holds the optic nerve, which sends information to the brain, and blood vessels. Plaquenil can produce pigment changes in the macula of the retina. The retina is the part of the back of the eye that you see with. The macula is the central part of the retina responsible for central fine vision. With Plaquenil related toxicity, the pigment in the macula can change and alter vision by producing blurring and distortion of objects. Periodic eye exams in patients taking HCQ is to recognize toxicity, if it occurs, at the earliest 17 possible stage. Toward this end, the American Academy of Ophthalmology AAO has 18 published guidelines for retinal toxicity monitoring 4, 5. 19 Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Retinal exam for plaquenil Despite Plaquenil dosing recommendations, retinal toxicity., Conditions Plaquenil-related Eye Problems Eugene Eye Care Hydroxychloroquine sulfate 200 mg film coated tabletsPlaquenil reviewsNovo-chloroquine 250 mg side effectsEffects of plaquenil on the eyes When you visit an ophthalmologist for a Plaquenil eye exam, your doctor will perform different tests to detect the presence or extent of retinal damage due to this medication. A Plaquenil screening may include a visual field test, OCT imaging, multifocal ERG, and photos of your eye. Plaquenil Eye Exams - Rock Hill Eye Center. AMERICAN COLLEGE OF RHEUMATOLOGY. Multimodal Imaging in Plaquenil Toxicity. Apr 17, 2017 The goal for Plaquenil Screening to detect toxicity early and stop the medication as soon as possible if present. Functional test that focus on central field sensitivity may pick up early toxicity. Early structural changes may be difficult to detect and high resolution optical coherence tomography OCT and fundus autofluorescence are very. The American Academy of Ophthalmology released an updated set of screening recommendations for hydroxychloroquine Plaquenil and chloroquine to account for the many studies that have shown the effects of these medications on the retina 1. It succinctly makes the case for screening, and Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity. Plaquenil-induced toxicity usually will not occur before five years of taking the drug.