It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine free base Will plaquenil help with fatigue That’s a very interesting reaction to plaquenil. I was on it for four or five years personally, and did well. But it sounds like you did this correctly. Started off slow. Considered whether the change in your mental state could be related, came off the med and had an improvement. Jan 12, 2014 These can affect your mood, but also your vitamin levels which could contribute to anxiety and depression. You might ask to have your Vit D and B12 checked, also sodium when mine is low it feels like an anxiety attack. You could purchase a small light box inexpensive and use it to increase the spectrum of light. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil and mood changes Anxiety and Plaquenil Has anyone experienced mood. - LUPUS UK, Plaquenil causing mood changes and depression? Plaquenil and anesthesia Sep 13, 2019 -Patients with retinal changes may be asymptomatic initially, or may have scotomatous vision with paracentral, pericentral ring types, temporal scotomas, and abnormal color vision.-Corneal changes including edema and opacities can be symptomless or may cause disturbances such as haloes, blurring of vision or photophobia. They may be transient. Plaquenil Side Effects Common, Severe, Long Term -. Rx Side Effects New Plaquenil Guidelines and More - American.. Will you have Mood swings with Plaquenil - eHealthMe. Dec 31, 2006 I am sorry you are experiencing such mood swings.fun at all. I was lucky in that I never experienced ANY side effects from the Plaquenil at least not that I attributed to the medication. However, I have a friend who started taking Plaquenil and she said it made her feel awful.she had the flu.she stopped. These side effects include dizziness, drowsiness, headache, mood changes, anxiety, and a litany other related issues. Like with any side effect, one must consider the tradeoffs. If I don’t take the RA meds, I’m more prone to permanent tissue damage. If I take the meds, I have to learn to manage the brain fog. I am on my third day of 400mg of Plaquenil, and I am feeling pretty depressed for no apparent reason. Does anyone know if Plaquenil can cause depression or mood swings? Does it go away after you have been on it for a while? I am very new to all of this, so thanks for any advice!