Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil bleeding gums Plaquenil allergic rash Chloroquine and fertility Rheumatoid Arthritis What Is Chloroquine Aralen? Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne. TFEB transcription factor EB is a master regulator for transcription of genes involved in autophagy and lysosomal biogenesis Sardiello et al, 2009; Settembre et al, 2011. Activity of TFEB is inhibited upon its serine phosphorylation by the mammalian target of rapamycin mTOR. Uses Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine tfeb Activation of lysosomal function in the course of autophagy., STUB1 regulates TFEB‐induced autophagy–lysosome pathway. Fluoroquinolones and chloroquineHydroxychloroquine and chloroquin sarcoidosis However, inhibiting ALP by chloroquine or TFEB knockdown abrogated the protective effect of Chir-99021 or STI-571 on MPP +-induced cell death. These results suggested that c-Abl/GSk-3β inhibition could protect neurons from MPP +-induced cell death which is dependent on the enhanced function of ALP mediated by TFEB. Role of c-Abl-GSK3β Signaling in MPP+-Induced Autophagy.. Chloroquine Oral Uses, Side Effects, Interactions.. Small-molecule TFEB pathway agonists that ameliorate.. The present invention relates to a composition comprising an autophagy enhancement compound. Small molecules that are able to enhance autophagy and lysosome biogenesis by activating the gene TFEB which can prevent the accumulation of toxic protein aggregates in treating neurodegenerative diseases are disclosed. Uses of Chloroquine It is used to treat or prevent malaria. It is used to treat a type of bowel infection. It may be given to you for other reasons. TFEB accommodates the autophagy lysosome pathway in chondrocytes. Recent evidences in cell biology regard TFEB as a master controller of the ALP, but its function in chondrocyte has not been reported.