Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Baseline eye exam plaquenil Lupus therapy allergy to plaquenil Chloroquine is indicated to suppress or treat acute attacks of Chloroquine is absorbed rapidly and completely from the gastro Suppress or treat acute attacks of malaria. It does not preven Absorbed rapidly by GI system. Concentrates in RBC, liver, kid It's direct effects are on the parasite. It is caused by protozoan parasites belonging to the Plasmodium genus and transmitted by an infected female Anopheles mosquito. This disease affects mainly children aged less than 5 years. Among the four species of malarial parasite which infect humans. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. What is the mechanism of action of chloroquine Aralen chloroquine Malaria Drug Side Effects & Dosage, PDF Malaria Mode of action of chloroquine and mechanism of. Plaquenil manufacturer covisPlaquenil usual dosageChloroquine ph 500 mg tabletAcr abstracts plaquenilPlaquenil toxicity ocular Mechanism of Action Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. Aralen Chloroquine Uses, Dosage, Side Effects.. CHLOROQUINE PHOSPHATE, USP. Hydroxychloroquine - Wikipedia. An important mode of action of chloroquine and hydroxychloroquine is the interference of lysosomal activity and autophagy. Chloroquine has a negative inotropic action, inhibits spontaneous diastolic depolarization, slows conduction, lengthens the effective refractory period and raises the electrical threshold. This results in depression of contractility, impairment of conductivity, decrease of excitability, but with possible abnormal stimulus re-entry mechanism. Two mechanisms are thought to be involved in chloroquine accumulation into the P. falciparum vacuole acidic trapping due to low vacuolar pH and chloroquine binding to heme or heme related species. It is reasonable to assume that PfCRT does not directly affect the molecular mechanism of chloroquine-HM binding.