Additionally, another exception occurred while executing the custom error page for the first exception. The information you’re looking for cannot be found, it may be temporarily unavailable or permanently removed. How to tell if plaquenil is causing blindness Hydroxychloroquine malaria prophylaxis dose Hydroxychloroquine 3d Chloroquine phosphate fish treatment Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Results SD-OCT images demonstrated loss of photoreceptor inner segment/outer segment IS/OS junction and a downward “sink-hole” displacement of inner retinal structures in areas of hydroxychloroquine toxicity corresponding to HVF 10-2 defects and ophthalmoscopic clinical examination findings. I have been on plaquenil since October of 2013. I started on 50 mg to avoid side effects then upped to 100 and finally to 150. I did experience the GI side effects but they have mostly passed. I do have horrible constipation though and I am not sure if this is due to the plaquenil or to the disease itself. All I know is its a new symptom for me. If the problem continues, please visit our support portal. Try refreshing the page, or returning to the homepage. Plaquenil oct changes Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Spectral-Domain Optical Coherence Tomography and Adaptive. Average dose for plaquenil is 1 tablet dailyHydroxychloroquine sulfate side effects rheumatoid arthritisPharmacokinetics of quinine chloroquine and amodiaquine Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Recommendations on Screening for Chloroquine and.. Plaquenil causing mood changes and depression?. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Although rare, Plaquenil can cause significant toxicity to the eye with prolonged use. Also, Plaquenil may have various systemic side effects that are not related to the eyes. These too are rare and include nerve weakness, hallucinations, psoriasis and changes in hair color. The eye complications are the most serious and worrisome. In early toxicity there are no visible signs, but field, OCT and mfERG changes can be detected. If abnormalities are present only unilaterally, investigate other causes besides hydroxychloroquine toxicity see “Differential Diagnosis of Bull’s-Eye Maculopathy”. Mechanism of Toxicity On SD-OCT, loss or thinning of the parafoveal and perifoveal photoreceptor layer and focal disruption of outer segment laminations are consistent with toxicity 13. These changes on SD-OCT can be seen before funduscopic abnormalities are present. Wider angle scans or scans across the vascular arcades are important for Asian eyes 6.