It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Chloroquine cos-7 What is chloroquine aralen Replacement for hydroxychloroquine Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. There are limited data on hydroxychloroquine teratogenicity. Chloroquine is teratogenic in rats after administration at very high, supratherapeutic doses, i.e. between 250 – 1500 mg/kg/day, showing a fetal mortality rate of 25% and ocular malformations anophthalmia and microophthalmia in 45% of foetuses in the 1000 mg/kg/day group. Diagnostic Tests for Hydroxychloroquine - Teratogenic Agent including blood tests, urine tests, swabs, diagnostic tests, lab tests, and pathology testing. About Us Bookmark this page The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Hydroxychloroquine teratogenicity Hydroxychloroquine - Wikipedia, Plaquenil-Hydroxychloroquine sulfate 200mg Film-coated. Generalized granuloma annulare hydroxychloroquineTaking plaquenil while having infectionsAralen malaria medicationHydroxychloroquine diabetes medscape The teratogenic risk related to the use of hydroxychloroquine is very low. Chloroquine may be used at prophylactic doses for malaria. In other situations, if continuation of the therapy is required for good control of the treated disease, the lowest possible dose should be used during pregnancy. Immunosuppressive drugs and fertility. Diagnostic Tests for Hydroxychloroquine -- Teratogenic.. Hydroxychloroquine Use During Pregnancy. Pharmacokinetics Following a single 200 mg oral dose of PLAQUENIL to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 daysthe same study, the plasma peak concentration was 50.3 ng/mL reached in 3.74 hours with a half-life of 2963 hours 123.5 days. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. In detail, the use of hydroxychloroquine was associated with both a lower incidence of fetal loss and placenta-mediated complications P =.05. Hydroxychloroquine showed beneficial effect on the overall duration of the gestation P =.034, with a marginally statistical benefit on reduction of the rate of preterm births P =.06.