B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. How long before plaquenil works Hydroxychloroquine and trametinib RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Drug-induced nail disease is diagnosed when a medication affects nail growth or structure. Drugs may cause Changes to the shape of the nail nail deformity Changes in the texture or composition of the nail nail dystrophy Abnormality of the tissues around the nail paronychia Pigmentation of the nail plate. Some changes in your nails are due to medical conditions that need attention. See your doctor if you have any of these symptoms discoloration dark streaks, white streaks, or changes in nail color B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Plaquenil nail changes Plaquenil Side Effects Common, Severe, Long Term -, Drug-induced nail disease DermNet NZ Hydroxychloroquine widely usedHydroxychloroquine and hearing loss To analyze the risk factors for toxic effects, we performed a case-control study comparing these 24 patients with SLE with 517 patients with SLE in the PLUS Plaquenil LUpus Systemic Study who were treated with HCQ and did not have HCQ-induced pigmentation PLUS Study Identifier NCT00413361. Hydroxychloroquine-Induced Pigmentation in Patients With.. Nail Abnormalities Symptoms, Causes, and Prevention. Drug-Induced Nail Changes Counting to 10. This means many people taking Plaquenil for RA are taking a dose of 400mg a day or higher. Pigment deposits in the retina can cause vision changes, according to Steven Ofner, M. D. of Eugene Oregon Eye Care. Signs of retinal damage include blurry or distorted vision, flashes of light or floaters, or loss of night vision. Re Plaquenil side effect hairloss I think vrs. diseases can damage hair. My only sis is hypothyroid; hers became very coarse & she lost a lot of it, too evenly spread out, not in patches. One of the potential long-term side-effects of using anti-malarial medications such as hydroxychloroquine Plaquenil, chloroquine, and quinacrine is the development of dark-colored patches on the skin. They often appear brown, black, or black and blue and tend to develop on the legs, especially around the shins.