Pharmacokinetics of quinine chloroquine and amodiaquine

Discussion in 'Canadian Pharmacy Drugs Online' started by noname_sp, 01-Mar-2020.

  1. DoEvent Guest

    Pharmacokinetics of quinine chloroquine and amodiaquine

    It is bioactivated hepatically to its primary metabolite, N-desethylamodiaquine, by the cytochrome p450 enzyme CYP2C8. Among amodiaquine users, several rare but serious side effects have been reported and linked to variants in the CYP2C8 alleles.

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    Concomitant administration of Mefloquine and quinine or chloroquine may increase the risk of convulsions. Ocular Effects Eye disorders, including but not limited to optic neuropathy and retinal disorders, have been reported during treatment with Mefloquine. Chloroquine CQ, a 4-aminoquinoline compound, has been used for the prophylaxis and treatment of malaria. It acts on the ring forms of the parasites, which are relatively resistant to the action of quinine 23. It is the first-line treatment for P. falciparum complicated malaria and is a treatment option for P. falciparum uncomplicated malaria in chloroquine-resistant regions. 25–27 Quinine seems to act against Plasmodium spp. by inhibiting haem polymerase that leads to toxic haem levels. 27 Quinine metabolism is interesting because acute malaria influences absorption, the binding-protein fraction, CYP450 activity and excretion of quinine.

    People who are poor metabolizers of amodiaquine display lower treatment efficacy against malaria, as well as increased toxicity. CYP2C8*1 is characterized as the wild-type allele, which shows an acceptable safety profile, while CYP2C8*2, *3 and *4 all show a range of "poor metabolizer" phenotypes.

    Pharmacokinetics of quinine chloroquine and amodiaquine

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  6. Quinine is active against the Plasmodium falciparum strain and may be used where other medicines – such as chloroquine or artesunate – are either ineffective or unavailable. Quinine is most effective at treating uncomplicated malaria. It becomes progressively less effective at treating more complicated, severe forms of malaria.

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    Parenteral quinine should be given by slow intravenous infusion and a loading dose is recommended in severe infections. Chloroquine t1/2 beta 6-50 days and mefloquine t1/2 beta 6-33 days have extensive tissue distribution and prolonged activity after a single dose. Pharmacokinetics of chloroquine in Thais plasma and red-cell concentrations following an intravenous infusion to healthy subjects and patients with Plasmodium vivax malaria. Br. J. The quinoline antimalarials quinine, chloroquine, amodiaquine, primaquine and mefloquine comprise the majority of world antimalarial drug usage. These compounds have narrow therapeutic ratios. None of them is younger than twenty years old. The object of this article is to illustrate howthe treatmentofmalaria.

  7. gagin Guest

    This anti-malarial agent is an older disease-modifying anti-rheumatic drug and is used by rheumatologists for patients who try and fail or fear trying immunomodulator and biologic therapy. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil Hydroxycholorquine - Arthritis - MedHelp
  8. MissRight Moderator

    Hydroxychloroquine Oral Route Description and Brand Names - Mayo Clinic Hydroxychloroquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines eg, chloroquine may not work. Hydroxychloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria.

    Risk of Nonmelanoma Skin Cancer Associated With the Use of.