Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Plaquenil and hair dye Hydroxychloroquine what to assess before taking it Unfortunately, in some people with more advanced retinopathy, stopping hydroxychloroquine treatment does not prevent the disease from getting worse. At the moment there is no treatment for hydroxychloroquine toxicity. If the disease does progress a person may experience significant loss of vision over time. You will be Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Hydroxychloroquine retinopathy after short-term therapy Hydroxychloroquine Plaquenil Toxicity and., Hydroxychloroquine Plaquenil Toxicity and Recommendations. Is chloroquine injection safe in early pregnancyIcd 10 code for plaquenil therapyPlaquenil causes lowcalcium levelsDrug interactions with plaquenilPlaquenil dosage Most screening guidelines recommend screening for HCQ/CQ retinopathy after 5 years of drug therapy with annual screening. Baseline evaluation, in some form, is widely recommended to identify those. Hydroxychloroquine retinopathy Eye. Recommendations on Screening for Chloroquine and.. Drug spotlight on hydroxychloroquine Lupus Foundation of.. Studies have shown that patients who have manifested with retinopathy have traces of Plaquenil metabolites in their erythrocytes, plasma, and urine even after 5 years of discontinuing the medication 1, 2, 3. After 5 years of therapy, an ocular examination, 10-2 threshold field testing and any one objective testing is recommended 1, 4. These long-term observations confirmed the previously published observations based on short-term studies that chloroquine retinopathy tends to remain stable after therapy is discontinued, although. IMPORTANCE Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull's eye maculopathy.