They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Chloroquine transfection protocol Plaquenil use in macular degen Adverse effects of chloroquine Plaquenil eye exam coding Plaquenil works by suppressing the immune system. Unfortunately you can't tell it to attack just the germs so you suppress all of its function to spare your healthy tissue- in your husband's case, his eyes, mouth, throat. NOTE Plaquinil and hydroxychloroquine are essentially the same drug. The same effects should be expected from both drugs. 2. No, his immune system should not be forever compromised. My gyn oncologist was concerned that the Plaquenil may affect my immune system to ward of the hpv since we all know a good immune system is needed to fight the virus --- He understands the RA pain conundrum I have. Howdy LadyDi, sorry you are having problems. Plaquenil is what is call an immune modifier. It is not a immune suppressant. Originally it was used to prevent Malaria. Then it was discovered to be effective for the treatment of Lupus. Plaquenil has the least amount of side affects in treating auto immune disorders. Fungal infections can range from mild to life-threatening. Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection. Does plaquenil suppress the immune system Weakened immune system? DailyStrength, Plaquenil and its affect on the immune system DailyStrength Quinine and chloroquineNosebleed plaquenilHydroxychloroquine retinal toxicity retina replacementSide effects coming off plaquenil Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Your rheumatologist will monitor you closely for any side effects associated with methotrexate such as liver test abnormalities, pneumonitis, or infections. Almost all autoimmune diseases require the immune system be suppressed to some degree, because ‘overactivity’ of the immune system is what drives the illness. Methotrexate Does it weaken my immune system?. Does Plaquenil supress the immune system?. Plaquenil. They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Specifically, corticosteroids and TNF tumor necrosis factor. I've been on 400 mg plaquenil since last Dec 2007. My symptoms have been under the control. Some literatures recommended not to take this medicine while on AP. Others seemed to not worry about it. Interesting thing is “Plaquenil is an anti parasite medicine developed to treat malaria. Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus.