In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Is plaquenil a steroid Hydroxychloroquine and antacids Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. OBJECTIVE To describe the clinical features and outcome of hydroxychloroquine HCQ-induced pigmentation in patients with systemic lupus erythematosus SLE. Pigmentation from heavy metal toxicity may be permanent; Iron can cause a dark brown pigmentation siderosis at the site of inadvertent subcutaneous injection; Excessive gold, previously used in the treatment of rheumatic diseases, can cause diffuse golden brown pigmentation; Ingested silver salts may induce a diffuse greyish pigmentation argyria Aug 14, 2013 Most commonly, its use can result in hyperpigmentation of the forehead, hard palate, forearms, and shins 2, 3 ; it can also cause pigmentation that appears on the cheek mucosa and nails 6, 11. The development of hydroxychloroquine-associated cutaneous dyschromia is not so rare and can present as black. Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine-induced pigmentation Plaquenil Side Effects Common, Severe, Long Term -, Drug-induced hyperpigmentation DermNet NZ Chloroquine transfection protocol Introduction Hydroxychloroquine is an antimalarial agent widely prescribed in internal medicine, rheumatology and dermatology. Its use can be complicated by various side effects including skin pigmentation. Objectives The aim of the study is to review epidemiological, clinical features and risk factors of hydroxychloroquine-induced pigmentation. Hydroxychloroquine-induced hyperpigmentation in systemic.. Hydroxychloroquine-Associated Hyperpigmentation Mimicking.. Skin Pigmentation with Hydroxychloroquine Plaquenil — Donovan Hair Clinic. We report two cases of hydroxychloroquine‐induced hyperpigmentation presenting in a 50‐year‐old Caucasian female case 1 and a 78‐year‐old female case 2, both receiving 400 mg per day. Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated with hydroxychloroquine for 4–5 years. Blue–grey pigmentation of the skin affects up to 25% of patients taking hydroxychloroquine, especially where there has been bruising. Transverse pigmented nail bands and mucosal pigmentation have also been reported. Rashes may occur in up to 10% of patients, most commonly morbilliform or psoriasiform. Hydroxychloroquine-Induced Hyperpigmentation. From the Departments of *Rheumatology and †Dermatology, Walter Reed National Military Medical Center; and ‡Uniformed Services University of the Health Sciences, Bethesda, MD. No financial support was received for this study. The authors declare no conflict of interest.