Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine resistant malaria haiti Effects of stopping hydroxychloroquine Plaquenil actually has weight loss as a side effect - not that I can report it from experience darn it! Read More Also, if the reason you're losing weight is because of loss of appetite, you should start addressing that right now, given your low baseline weight. Aug 14, 2017 Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil and weight loss surgery Protecting your eyesight when taking Plaquenil Lupus., Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil anti-agingChloroquine side effects treatmentHydroxychloroquine hand osteoarthritis The plaquenil has caused a weight gain of about 20-25 pounds for me. Since I was diagnosed with MCTD a year ago, Plaquenil has been the only medication besides eye supplements, thyroid meds - been stable for years, and most recently Evoxac that I have been given. Plaquenil & Weight Gain/Loss -. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil Side Effects Common, Severe, Long Term -. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling especially of the face/tongue/throat, dizziness, trouble breathing. This is not a complete list of possible side effects. Retinopathy can lead to sight loss so it’s important that you keep your doctor informed of any changes you experience in your vision. If you are using Plaquenil, The Wellish Vision Institute recommends regular eye exams to help catch any change that may be subtly occurring. Severe and irreversible retinal damage has been reported with the use of hydroxychloroquine. Risk factors for retinal damage include daily doses more than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than 5 years, subnormal glomerular filtration, use of concomitant drugs such as tamoxifen, and concurrent macular disease.