Chloroquine phosphate resistant malaria

Discussion in 'Discount Prescriptions' started by Alias, 27-Feb-2020.

  1. makeev1973 Well-Known Member

    Chloroquine phosphate resistant malaria


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Medicines for the Prevention of Malaria While Traveling Chloroquine Aralen™. Chloroquine also known as chloroquine phosphate is an antimalarial medicine. It is available in the. United States by prescription only. It is sold under the brand name Aralen, and it is also sold as a generic Chloroquine phosphate or hydroxychloroquine sulfate Plaquenil can be used for prevention of malaria only in destinations where chloroquine resistance is not present see Chapter 2, Yellow Fever Vaccine & Malaria Prophylaxis Information, by Country. Prophylaxis should begin 1–2 weeks before travel to malarious areas. Chloroquine is an aminoquinoline used for the prevention and therapy of malaria. It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine phosphate resistant malaria

    Guidelines for Treatment of Malaria in the United States., Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health CDC

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  3. Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance.

    • Chloroquine Resistance in Plasmodium falciparum Malaria..
    • Chloroquine - LiverTox - NCBI Bookshelf.
    • Chloroquine Does NOT Cure Coronavirus! Dubawa.

    Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. Chloroquine is indicated in suppressive treatment and acute attacks of malaria due to P. vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. Antacids and kaolin can reduce the absorption of chloroquine; separate by 4 hours. Concomitant use of cimetidine should be avoided. Chloroquine phosphate is calculated as the base. Chloroquine was an essential element of mass drug administration campaigns to combat malaria throughout the second half of the 20th century, and remains one of the World Health Organization’s essential medicines. However, after the malaria parasites Plasmodium falciparum and Plasmodium vivax began exhibiting resistance to the drug in the 1960s and 1980s, respectively, it was replaced by similar antimalarial compounds and combination therapies.

     
  4. bruno99 Well-Known Member

    A 45-year-old black female presented with no ocular or visual complaints. However, her medical history was significant for a recent diagnosis of lupus. Plaquenil and blood tests? How weird. - Hughes Syndrome Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Discontinued Plaquenil.other options?
     
  5. flakyblaze New Member

    Factors that affect local malaria transmission patterns can change rapidly and from year to year, such as local weather conditions, mosquito vector density, and prevalence of infection. Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health CDC WHO Model Prescribing Information Drugs Used in Parasitic. Mefloquine Dosage Guide with Precautions -
     
  6. REG-RIPN User

    How long did Plaquenil/Hydroxychloroquine take. Plaquenil was one of the first treatments i had too - again i was told it needed to be used with other meds. I think i had it for a year and then moved onto more 'tough' stuff. I have just started taking it again as now have drug induced lupus and as yet can't say its working. I keep trying tho - and realise the only way to control this beastly.

    Plaquenil -
     
  7. mishqa35 Well-Known Member

    Chloroquine as prophylaxis may offer pregnant women. When comparing chloroquine and sulfadoxine-pyrimethamine as intermittent therapy for the treatment of malaria in pregnant women — in a setting of high resistance to sulfadoxine-pyrimethamine.

    Prophylactic use of antimalarials during pregnancy