While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "Hydrochloroquine (Plaquenil) has been a blessing for me. Side effects of hydroxychloroquine 400 mg Plaquenil and trintellix interactions For Sjogren's Syndrome "I’ve been on plaquenil 400mg once a day for 6 months now due to Sjogrens. If your are wondering how long the plaquenil takes to work, it took about 3 months before I starting feeling better. Now at 6 months I’m noticing more symptoms. User Reviews for Plaquenil to treat Rheumatoid Arthritis. The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. My doctor wants me to start taking Plaquenil tomorrow. I have read some of your comments about nausea, heartburn, indigestion, and hair loss. I am wondering how long it will take to get any of these side effects if at all after I start Plaquenil? One day, one week, one month, one year? Thank. I do occasionally experience dry eyes and a little scalp itch but asserting that it's caused by Hydrochloroquine would be anecdotal at best. It took about 5 weeks to take effect but my RA is basically a non factor now. How long to try plaquenil PLAQUENIL" Rheumatoid Arthritis Community - Support Group, Plaquenil User Reviews for Rheumatoid Arthritis at Can plaquenil cause hivesIs plaquenil a sulfonamide May 30, 2005 I have been diagnosed with some form of seronegative arth. reative? who knows. I take 500 mg of naproxen twice a day been on it since Jan. it saved me from pain so bad I was nearly always on the verge of tears and started Plaquenil 3 months ago. So far no improvement. In fact about 1.5. How long to give Plaquenil a try? ProHealth Fibromyalgia.. How long taking Plaquenil before side effects DailyStrength. Plaquenil -. Plaquenil is also an option for those who try and fail biologic drugs, cannot tolerate biologics or fear potential side effects linked to biologic DMARDs. How It Works Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. I have been on Plaquenil for several years, first the generic Plaqenil has no coating to protect your stomach lining. If you have side affects first try brand. I know Dr. s Say there is no difference."But" composition of the drug may not affect the effectiveness of drug but it will affect the way it is absorbed in your system. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives.