Chloroquine bioavailability

Discussion in 'Northwest Pharmaceuticals Canada' started by Aloris, 03-Mar-2020.

  1. Slavier New Member

    Chloroquine bioavailability


    In addition, the impact of the patient’s physiopathological status and ethnic origin on chloroquine pharmacokinetics is discussed. In humans, chloroquine concentrations decline multiexponentially. The drug is extensively distributed, with a volume of distribution of 200 to 800 L/kg when calculated from plasma concentrations and 200 L/kg when estimated from whole blood data (concentrations being 5 to 10 times higher).

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    Chloroquine bioavailability in healthy males was examined following oral coadministration of 600 mg with three common Sudanese beverages, Aradaib Tamarindus indica, Karkadi Hibiscus sabdarifa and Lemon Citrus limetta and drinking water. Mary F. Hebert, in Clinical Pharmacology During Pregnancy, 2013. 3.2.10 Volume of distribution. Volume of distribution is not a physical space, but rather an apparent one. Volume of distribution is the apparent volume needed to account for the total amount of drug in the body if the drug was evenly distributed throughout the body and in the same concentration as the site of sample collection. Chloroquine bioavailability in healthy males was examined following oral coadministration of 600 mg with three common Sudanese beverages, Aradaib Ta We use cookies to enhance your experience on our continuing to use our website, you are agreeing to our use of cookies.

    Following administration chloroquine is rapidly dealkylated via cytochrome P450 enzymes (CYP) into the pharmacologically active desethylchloroquine and bisdesethylchloroquine. Chloroquine is 60% bound to plasma proteins and equally cleared by the kidney and liver.

    Chloroquine bioavailability

    Pharmacokinetics of Chloroquine and Monodesethylchloroquine., Volume of Distribution - an overview ScienceDirect Topics

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  4. Desethylchloroquine and bisdesethylchloroquine concentrations reach 40 and 10% of chloroquine concentrations, respectively; both chloroquine and desethylchloroquine concentrations decline slowly, with elimination half-lives of 20 to 60 days.

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    The following bioavailability parameters Cmax, tmax, and AUC 0-24, AUC 0-∞ were calculated. The peak serum concentration Cmax of ciprofloxacin was 3.42 ± 0.32 μg/mL, which dropped to 2.8 ± 0.18 μg/mL when chloroquine was taken together with ciprofloxacin. We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. Ampicillin In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin. An interval of at least two hours between intake of ampicillin and chloroquine should be observed. Cyclosporine After introduction of chloroquine oral form, a sudden increase in serum cyclosporine level has been reported.

     
  5. Faunskler Guest

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine Uses, Side Effects & Warnings - Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Chloroquine Uses, Side Effects, Dosage & Interactions
     
  6. Stinki Well-Known Member

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