Chloroquine use in sle

Discussion in 'Online Canadian Pharmacy' started by Jorm, 23-Feb-2020.

  1. Synodontis Well-Known Member

    Chloroquine use in sle


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Interestingly, chloroquine was widely used in Japan for a variety of clinical indications from 1955 through the early 1970s, including malaria, RA, and SLE, as well as in diseases such as epilepsy and chronic nephritis, in which baseline risk of retinal toxicity was likely higher to begin with 16. The dangers associated with chloroquine use were compounded by the absence of rigorous safety screening protocols, despite the known potential for retinal toxicity. Initial dose for the treatment of SLE, 400mg×2/day, is about the dose used in one of the studies above. Maintenance dose would keep the serum concentration constant. Assuming HCQ is effective, it would most definitely be protective in doses used in SLE patients. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine use in sle

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  6. Chloroquine can be used to kill malaria parasites living in red blood cells but the medication may not necessarily be efficient at killing these parasites in other body tissues. Doctors often prescribe this medication as part of certain treatment plans for lupus and other immune system diseases.

    • What Is the Difference between Hydroxychloroquine and..
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    Hydroxychloroquine HCQ, is a 4-aminoquinoline drug used widely in autoimmune disease, but has also been employed for the treatment of malaria,1 where it is reported as being half as toxic as the closely-related chloroquine CQ yet equally active against Plasmodium falciparum.2 In UK travel medicine, three drug regimens atovaquone–proguanil, mefloquine or doxycycline are currently recommended for use in sub-Saharan Africa and other areas with high transmission rates of CQ-resistant P. In SLE patients the cytokine levels were measured just before and three months after starting chloroquine treatment at a dose of 125 mg twice daily. Although the majority of SLE patients had a low systemic lupus activity measure SLAM index, the levels of IL-6, IL-18 and TNF-alpha were significantly higher than in the control group. Chloroquine, although grouped with hydroxychloroquine in table 2 of this article, is not routinely used in the management of SLE either in or out of pregnancy due to increased tissue

     
  7. Soprano57 Moderator

    Tafenoquine is an 8-aminoquinoline antimalarial drug related to primaquine. Tafenoquine Dosage Guide with Precautions - Tafenoquine Advanced Patient Information - Tafenoquine plus chloroquine for the treatment and relapse.
     
  8. zoomer New Member

    Plasmodium is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects. Chloroquine Indications, Side Effects, Warnings - Chloroquine Oral Uses, Side Effects, Interactions, Pictures, Warnings. Fatima Notes Dna Gene
     
  9. Antracit Guest

    Swollen Lymph Nodes Causes and Treatment Swollen lymph nodes caused by cancer may not shrink back to normal size until the cancer is treated. Cancer treatment may involve removing the tumor or any affected lymph nodes. It may also involve chemotherapy to shrink the tumor. Your doctor will discuss which treatment option is best for you.

    Swollen Lymph Nodes in Neck on One Side - Health Hearty
     
  10. Mop Well-Known Member

    Aralen Chloroquine Uses, Dosage, Side Effects. Apr 02, 2019 Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine.

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