Chloroquine mechanism of action autophagy

Discussion in 'Plaquenil 200mg' started by Akustika, 29-Feb-2020.

  1. pt84 Moderator

    Chloroquine mechanism of action autophagy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

    Chloroquine treatment of cells Hydroxychloroquine fatigue

    The mechanism through which chloroquine is acting on cancer cells has mainly been attributed to the inhibition of autophagy as a consequence of its lysosomotropic properties 13, 24. Consistently, we also observed a strong inhibitory effect of chloroquine on autophagy in the established PDAC cell lines previously used in the cited studies. Chloroquine is a 9-aminoquinoline that has been known since 1934. Specifically synthesised to be used as an antimalarial agent, chloroquine was subsequently shown to have immunomodulatory properties that have encouraged its application in the treatment of autoimmune diseases such as rheumatoid arthritis. An important mode of action of chloroquine and hydroxychloroquine is the interference of lysosomal activity and autophagy. It is widely accepted that chloroquine and hydroxychloroquine accumulate.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine mechanism of action autophagy

    Chloroquine Modes of action of an undervalued drug., Effects of chloroquine on viral infections an old drug.

  2. Plaquenil and mctd
  3. Chloroquine has a long history of human use and is currently being tested as a sensitizing agent for certain cancers, making understanding its mechanisms of action both topical and important. Chloroquine is a lysosomotropic weak base, which in the monoprotonated form diffuses into the lysosome, where it becomes diprotonated and becomes trapped.

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    It has also been demonstrated that chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy inhibition, and the potential side effects of chloroquine therapy have also been cautiously discussed. This indicates that a more detailed understanding of chloroquine's anticancer mechanism is required in order to further develop this compound into an effective anticancer agent. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species ROS related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. In parallel with these findings, another study demonstrated that autophagy is a key mechanism for anti-leukemic effects of ATO in AML cell lines and leukemic progenitors from AML patients, and this induction of autophagy flux is associated with mitogen-activated protein kinase kinase MEK/extracellular signal-regulated kinase ERK-dependent autophagic cell death.

     
  4. emg Moderator

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Plaquenil Side Effects Common, Severe, Long Term - Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.
     
  5. maju XenForo Moderator

    Selected from data included with permission and copyrighted by First Databank, Inc. Will you have Fingers that change color with Plaquenil. Common and Rare Side Effects for Plaquenil Oral Sudden visual changes in color perception - Doctors answer.
     
  6. meramo New Member

    Chronic Conditions What Is Autoimmune Disease Rash? Pain. Of course, simply having one or two of these symptoms does not guarantee that anyone is living with an autoimmune condition. It’s important to keep in mind that there are a variety of autoimmune skin conditions, and many of them come with different causes and symptoms. Types of Autoimmune Skin Diseases. Autoimmune disease rashes result from a.

    Psoriasis Associated with Plaquenil Hydroxychloroquine - Dr.