Had symtoms of malar rash, joint pain especially in hands, fatigue , dry eyes and dry skin . Had a biopsy of skin and confirmed cutaneous lupus. I was put on Plaquenil and for the past 8 years I have been fine with it . Now this year I have been having things pop up that are related to a low immune system. What happens is you mix hydroxychloroquine with alcohol Hydroxychloroquine plaquenil How long chloroquine tablets is good after expiration date Basically, the immune system is a bit out of control. Plaquenil works by suppressing the immune system. Unfortunately you can't tell it to attack just the germs so you suppress all of its function to spare your healthy tissue- in your husband's case, his eyes, mouth, throat. NOTE Plaquinil and hydroxychloroquine are essentially the same drug. Unlike other DMARDs, Plaquenil does not suppress the immune system. It changes something within the cell to decrease the inflammation. I've been on it 6 months and my joints, fatigue and nose/mouth ulcers have improved. I've had one cold since then, which isn't more than usual for me. As with other drugs that may suppress your immune system, talk to your doctor about any vaccines or surgeries you may have. In addition, be sure to notify him/her of any other medications, both prescription and over-the-counter, that you may be taking. Does anybody have any input concerning taking Plaquenil for long term therapy ? Some of my doctors think It is the Plaquenil causing it but then some say that Plaquenil is not an immunosuppressant drug that for some reason my immune system is out of wack . I tried to only take 100 mg to see if it would make a difference but I started with terrible joint pain and fatigue so I am back on the 200 mg a day. Hydroxychloroquine immune suppressant Hydroxychloroquine, Anyone on Hydroxychloroquine plaquenil - Autoimmune. Plaquenil rheumatoid arthritis dosage Overall, most serious fungal infections are rare, but they do happen. They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Medications that Weaken Your Immune System and Fungal.. Treating Lupus with Immunosuppressive Medications Johns.. Does hydroxychloroquine suppress the immune system - Answers.. Plaquenil works by suppressing the immune system. Unfortunately you can't tell it to attack just the germs so you suppress all of its function to spare your healthy tissue- in your husband's case, his eyes, mouth, throat. NOTE Plaquinil and hydroxychloroquine are essentially the same drug. The same effects should be expected from both drugs. Anti-DNA antibodies exert their pathogenic effects through deposition as immune complexes in the kidney or through the recognition of cross-reactive antigens in the kidney, while in situ deposition of an immune complex composed of DNA, anti-DNA antibody and IgG in the renal tissue leads to the activation of the complement system and causes a. A recent large study of people with cardiovascular disease found that hydroxychloroquine Plaquenil does not increase the risk of infection and methotrexate increases the risk of infection only slightly. The concern with immune suppression is that the virus could replicate more freely and cause more severe or extensive disease, says Dr. Winthrop.