Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil and yellow fever vaccine Plaquenil maculopathy risk Hydroxychloroquine • Methotrexate • IVIG Clinical practice as per literature favors use of dapsone or sulfasalazine. 30 Physical • Symptomatic dermographism • Cold urticaria • Delayed pressure urticaria Eosinophils and extracellular deposits of eosinophil granule proteins have been described in chronic idiopathic urticaria, delayed pressure urticaria, and solar urticaria. 25 Extracellular deposits of MBP have been observed as granular deposits and coating tissue fibers in the dermis, as well as in small blood vessel walls. 26 ECP may stimulate histamine release by mast cells and basophils. 27 By generating eicosanoid mediators and secreting neuropeptides, such as substance P, eosinophils. Delayed pressure urticaria DPU is characterized by swellings that develop at sites of sustained pressure on the skin several hours after the pressure is removed and can persist for days. DPU is generally difficult to treat successfully. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Delayed pressure urticaria hydroxychloroquine Chronic Urticaria Following Practice Guidelines, Pressure Urticaria - an overview ScienceDirect Topics Psoriasis plaquenilIs plaquenil a maoi Pressure urticaria may occur immediately after a pressure stimulus or more commonly, in delayed pressure urticaria, after a delay of 4–6 hours. Lesions can be induced by a variety of stimuli including standing, walking, wearing tight clothes or sitting on a hard surface. Delayed pressure urticaria DermNet NZ. Positive impact of chloroquine on delayed pressure urticaria.. Delayed Pressure Urticaria - HealthBoards. Numerous reports exist about its efficacy in cholinergic urticaria, cold urticaria, solar urticaria, heat urticaria, symptomatic dermographism, and delayed pressure urticaria. A double-blind RCT over 323 refractory urticaria patients with moderate-to-severe CSU demonstrated a high outcome with omalizumab 150 mg or 300 mg subcutaneous SC. The optimal duration of therapy with cyclosporine is not known. We typically treat patients at a dose required for complete or near-complete control of urticaria for three months and then taper the dose over several months, as tolerated. In the majority of patients, six to nine months of treatment is adequate. Delayed pressure urticaria is a physical urticaria where erythematous, often painful swellings occur at sites of sustained pressure on the skin, after a delay of several hours. If sought, it is present in up to 40% of patients with ordinary chronic "idiopathic urticaria" to a varying degree.