It typically happens in the evening or nighttime hours when you're sitting or lying down. Restless legs syndrome, also known as Willis-Ekbom disease, can begin at any age and generally worsens as you age. It can disrupt sleep, which interferes with daily activities. Does plaquenil lower immune system Malaria prophylaxis chloroquine resistant areas A number of diseases can cause stiff legs. These can be grouped very broadly into autoimmune, metabolic, and nervous system disorders. Many of these are thought to have genetic links, with research about treatments and cures still ongoing. The severity of symptoms often worsens over time as the conditions progress. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. What Are Side Effects of Plaquenil? Common side effects of Plaquenil include. nausea, vomiting, stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, headache, Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Medications also help many people with symptoms as abnormal, unpleasant sensations in their legs or feet. They do, however, consistently describe the desire to move their legs. Sometimes, symptoms disappear for periods of time, then come back. Simple self-care steps and lifestyle changes may help relieve symptoms. The sensations, which generally occur within the limb rather than on the skin, are described as: usually don't describe the condition as a muscle cramp or numbness. Does plaquenil caus stiff legs Experiences taking Plaquenil for Fatigue and Muscle Pain? - Inspire, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil and iplHow to stop itching from plaquenilCan you take phenylephrine with plaquenil You might feel stiffness the most when you first get up after time spent sitting — as when driving in the car — or after a night of sleep. If stiffness is chronic or gets worse with time, see a doctor to rule out arthritis or another medical condition. Otherwise, use simple stretches, water therapy and other movement to relieve your stiff legs. How to Relieve Muscle Stiffness in Legs. Skin Discoloration and Plaquenil - Arthritis Information. Muscle stiffness Causes, symptoms, and treatment. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. I have mild Lupus with no organ involvement. ANA+. For well over a year I have been experiencing ongoing, unrelenting muscle spasms and stiff, sore legs from the spasms which seem to happen most often in my lower body. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year.